Schuyler Van Engelenburg
What I do
Researching the mechanisms of viral biogenesis and educating the next generation of virologists and cellular biophysicits.
cellular biophysics, imaging, virology
I have an interdisciplinary background in the fields of virology, cellular biology, chemistry, and biophysics. My post-doctoral work at the National Institutes of Health focused on understanding how a single HIV particle is formed in an infected cell using single molecule imaging approaches. Here at DU I am focused on developing new imaging technologies to better understand how single viruses are "born", while also teaching both undergraduate and graduate students the fields of virology and cellular biophysics.
- Ph.D., Biochemistry, Universit y of Colorado, 2010
- BS, Chemistry, Fort Lewis College, 2005
- American Society for Microbiology
- Biophysical Society
Viral pathogens still plague our modern society despite the promise of highly effective therapies. Tremendous advances in our understanding of the genetics, biochemistry, and cellular pathology of viral infections are, however, beginning to fill the gaps in our knowledge and leading to new antiviral therapies. Nevertheless, many gaps remain in our understanding of the nanoscale and molecular dynamics of viral entry, replication, and assembly. As such, my laboratory focuses on developing cutting-edge multidisciplinary techniques to understand the host-viral interface on a truly molecular level. Specifically, this includes advanced superresolution microscopy techniques, protein chemistry and probe development, and computational image analysis to quantitatively understand the cellular, biochemical, and genetic drivers of HIV-1 assembly. To this end, my research is aimed at constructing molecularly accurate spatial and temporal models for HIV biogenesis. It is my hope that by pinpointing the weaknesses and dependencies of HIV assembly, that future research will lead to the development of new antiviral therapies targeting the assembly stage of the infection cycle.
- Identifying determinants of HIV-1 responsible for the nanoscale distribution and dynamics of virus assembly
- Defining the three-dimensional organization and dynamics of HIV-1 envelope using superresolution microsopy
- Boettcher Foundations Webb-Waring Biomedical Research Award
- Boettcher Foundation Collaboration Grant, Boettcher Foundation
- Webb-Waring Biomedical Research Award, Boettcher Foundation
- Listed as Top 25 Faculty Fiscal Year 2017 Research and Scholarship Annual Report, Office of Sponsored Research, University of Denver
- NICHD Mentor of the Year Award, National Institute of Child Health and Development